Respiratory involvement and immune status in yusho patients.

Respiratory involvement and immune status in yusho patients.

Clinical and experimental studies on respiratory involvement and alterations in immune status were carried out. Respiratory distress occurring in these patients has improved gradually for 14 years but still remains. Copious expectoration at an early stage of the disease may be related to the fact that a number of discrete polychlorinated biphenyls (PCBs) are distributed throughout the lung pare...

Past and current dermatological status of yusho patients.

Skin symptoms of "yusho" and their change thereafter are described. In the early stage, skin eruptions were the most prominent and impressive features of yusho. Acneiform eruptions and pigmentation were most conspicuous. With the passage of time, there is some improvement and most patients now have few eruptions, except for the severely intoxicated group. As for blood PCB analysis, the severely...

[Chemokine profile of Yusho patients].

Dioxins may have an impact on the human immunological system, which would increase the risk to develop allergic diseases, such as atopic dermatitis. In the present study, we measured serum levels of Th1- and Th2-favored chemokines in 233 Yusho patients who attended annual medical check-ups from 20.06 to 2009 and in 97 control subjects. Serum levels of CCL5, CCL17, and CCL27 in Yusho patients we...

[Estimation of urinary diacetylspermine in Yusho patients].

Polychlorinated biphenyls (PCBs) are known to cause the release of superoxide during the metabolic process. Therefore, it is suggested that the Yusho patients are exposed to oxidative stress caused by high concentrations of PCBs are still recorded in their serum. Recently, diacetylspermine (DiAcSpm) has been proposed as tumor markers or barometer of oxidative stresses. In order to estimate the ...

Immune status of leukemia patients.